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Article

Immunopharmacogenomics: Mechanisms of HLA-Associated Drug Reactions.

Clinical pharmacology and therapeutics - 1 Sept 2021

Deshpande Pooja, Hertzman Rebecca J, Palubinsky Amy M, Giles Jason B, Karnes Jason H, Gibson Andrew, Phillips Elizabeth J

Abstract excerpt

The human leukocyte antigen (HLA) system is the most polymorphic in the human genome that has been associated with protection and predisposition to a broad array of infectious, autoimmune, and malignant diseases. More recently over the last two decades, HLA class I alleles have been strongly associated with T-cell-mediated drug hypersensitivity reactions. In the case of abacavir hypersensitivity and HLA-B*57:01,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34143437
DOI: 10.1002/cpt.2343
PMCID: PMC8500648

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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