Article
Association of HLA-B and HLA-DRB1 polymorphisms with antithyroid drug-induced agranulocytosis in a Han population from northern China.
Scientific reports - 20 Sept 2017
He Yayi, Zheng Jie, Zhang Qian, Hou Peng, Zhu Feng, Yang Jian, Li Wenhao, Chen Pu, Liu Shu, Zhang Bao, Shi Bingyin
Abstract excerpt
Antithyroid drug (ATD)-induced agranulocytosis is associated with human leukocyte antigen (HLA) and nearby genes in Southeast Asian and European populations. The susceptibility of the Han population from northern China to ATD-induced agranulocytosis has not been reported. We evaluated the associations of genetic variants at the HLA-B and HLA-DRB1 loci and 32 candidate single nucleotide polymorphisms (SNPs) with...
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