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Article

HLA Allele-Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction.

Annual review of pharmacology and toxicology - 6 Jan 2022

Jaruthamsophon Kanoot, Thomson Paul J, Sukasem Chonlaphat, Naisbitt Dean J, Pirmohamed Munir

Abstract excerpt

Human leukocyte antigen (HLA) is a hallmark genetic marker for the prediction of certain immune-mediated adverse drug reactions (ADRs). Numerous basic and clinical research studies have provided the evidence base to push forward the clinical implementation of HLA testing for the prevention of such ADRs in susceptible patients. This review explores current translational progress in using HLA as a key...

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PMID: 34516290
DOI: 10.1146/annurev-pharmtox-052120-014115

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