Article

Infusion of CCR5 Gene-Edited T Cells Allows Immune Reconstitution, HIV Reservoir Decay, and Long-Term Virological Control

2021-03-01

Abstract excerpt

Antiretroviral therapy (ART) fails to fully restore immune function and is not curative. A single infusion of CCR5 gene-edited autologous CD4 + T cells (SB-728-T) led to sustained increases in CD4 + T cell counts, improved T cell homeostasis, and reduced the estimated size of the HIV reservoir. These outcomes were associated with the expansion and long-term persistence of a novel CCR5 gene-edited CD4 + T memory...

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Literature Corpus work: 3015320e-52e6-51d4-b99d-fbc5c597b708
DOI: 10.1101/2021.02.28.433290

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