Article
The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time.
Proceedings of the National Academy of Sciences of the United States of America - 17 Dec 2013
Josefsson Lina, von Stockenstrom Susanne, Faria Nuno R, Sinclair Elizabeth, Bacchetti Peter, Killian Maudi, Epling Lorrie, Tan Alice, Ho Terence, Lemey Philippe, Shao Wei, Hunt Peter W, Somsouk Ma, Wylie Will, Douek Daniel C, Loeb Lisa, Custer Jeff, Hoh Rebecca, Poole Lauren, Deeks Steven G, Hecht Frederick, Palmer Sarah
Abstract excerpt
The source and dynamics of persistent HIV-1 during long-term combinational antiretroviral therapy (cART) are critical to understanding the barriers to curing HIV-1 infection. To address this issue, we isolated and genetically characterized HIV-1 DNA from naïve and memory T cells from peripheral blood and gut-associated lymphoid tissue (GALT) from eight patients after 4-12 y of suppressive cART. Our detailed...
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