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Sequential IL-15 and TGF-β1 stimulation expands reprogrammed CD103⁺CD39⁺ effector CD8⁺T cells and enhances HIV control

2025-04-15

Abstract excerpt

During analytical treatment interruption (ATI), failure to contain tissue HIV reservoirs remains a major barrier to remission. We conditioned peripheral blood mononuclear cells with cues that promote tissue-resident memory differentiation, aiming to reprogram HIV- specific CD8 + T cells for these tissue microenvironments. Sequential IL-15/TGF-β1- stimulation expanded proliferative CD103 + CD39 + effector popula...

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Identifiers and source

Literature Corpus work
b96c5297-d291-5f05-aa47-dc748e9e7d82
DOI
10.1101/2025.04.09.647906
Open publication

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Sequential IL-15 and TGF-β1 stimulation expands reprogrammed CD103⁺CD39⁺ effector CD8⁺T cells and enhances HIV controlDOI 10.1101/2025.04.09.647906
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