Article

TCF-1 regulates the stem-like memory potential of HIV-specific CD8+ T cells in elite controllers

2020-01-08

Abstract excerpt

Although many HIV cure strategies seek to expand HIV-specific CD8+ T cells to control the virus, all are likely to fail if cellular exhaustion is not prevented. A loss in stem-like memory properties (i.e., the ability to proliferate and generate secondary effector cells) is a key feature of exhaustion; little is known, however, about how these properties are regulated in human virus-specific CD8+ T cells. We found...

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Literature Corpus work: 12b9eb1d-7ed0-5c8b-bf5a-1774ee7f8e27
DOI: 10.1101/2020.01.07.894535

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