Persistence of an intact HIV reservoir in phenotypically naive T cells.

Abstract excerpt

Despite the efficacy of antiretroviral therapy (ART), HIV persists in a latent form and remains a hurdle to eradication. CD4+ T lymphocytes harbor the majority of the HIV reservoir, but the role of individual subsets remains unclear. CD4+ T cells were sorted into central, transitional, effector memory, and naive T cells. We measured HIV DNA and performed proviral sequencing of more than 1900 proviruses in 2...

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• Anti-Retroviral Agents
• CD4-Positive T-Lymphocytes
• DNA, Viral
• HIV-1
• HIV Infections