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In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells.

Science translational medicine - 4 Feb 2015

Biasco Luca, Scala Serena, Basso Ricci Luca, Dionisio Francesca, Baricordi Cristina, Calabria Andrea, Giannelli Stefania, Cieri Nicoletta, Barzaghi Federica, Pajno Roberta, Al-Mousa Hamoud, Scarselli Alessia, Cancrini Caterina, Bordignon Claudio, Roncarolo Maria Grazia, Montini Eugenio, Bonini Chiara, Aiuti Alessandro

Abstract excerpt

A definitive understanding of survival and differentiation potential in humans of T cell subpopulations is of paramount importance for the development of effective T cell therapies. In particular, uncovering the dynamics in vivo in humans of the recently described T memory stem cells (TSCM) would be crucial for therapeutic approaches that aim at taking advantage of a stable cellular vehicle with precursor...

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PMID: 25653219
DOI: 10.1126/scitranslmed.3010314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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