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Article

Three-dimensional induced pluripotent stem-cell models of human brain angiogenesis.

Microvascular research - 1 Nov 2020

Linville Raleigh M, Arevalo Diego, Maressa Joanna C, Zhao Nan, Searson Peter C

Abstract excerpt

During brain development, chemical cues released by developing neurons, cellular signaling with pericytes, and mechanical cues within the brain extracellular matrix (ECM) promote angiogenesis of brain microvascular endothelial cells (BMECs). Angiogenesis is also associated with diseases of the brain due to pathological chemical, cellular, and mechanical signaling. Existing in vitro and in vivo models of brain...

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Identifiers

PMID: 32673611
DOI: 10.1016/j.mvr.2020.104042
PMCID: PMC7572715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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