Article

3D brain angiogenesis model to reconstitute maturation of functional human blood-brain barrier <i>in vitro</i>

2018-11-18

Abstract excerpt

0. Human central nervous system (CNS) vasculature in brain expresses a distinctive barrier phenotype, the blood–brain barrier (BBB), which protects the brain against harmful pathogens. Since the BBB contributes to low success rate in CNS pharmacotherapy by restricting drug transportation, the development of an in vitro human BBB model has been in demand. Previous models were unable to fully represent the complex...

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Literature Corpus work: a159a444-9cda-5bc5-ba21-274dd1c58eb1
DOI: 10.1101/471334

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