Article

NGFR-driven suppression of antigen presentation limits CD8+ T cell immunity and response to checkpoint blockade

2026-08-25

Abstract excerpt

Immune checkpoint blockade has revolutionized cancer therapy; however, numerous tumors remain resistant by adopting cellular states that impede immune recognition. In this study, we identify the nerve growth factor receptor (NGFR) as a regulator of immune evasion in head and neck squamous cell carcinoma (HNSCC). Genetic ablation of Ngfr resulted in impaired tumor growth in immunocompetent MOC2 HNSCC, while pharmac...

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Identifiers and source

Literature Corpus work: 2fb1c185-d229-51f3-9ad9-34549603bd37
DOI: 10.64898/2026.08.24.746602

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