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Article

Checkpoint blockade-induced CD8+ T cell differentiation in head and neck cancer responders

1 Jan 2022

Abstract excerpt

BACKGROUND: Immune checkpoint blockade (ICB) response in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) is limited to 15%-20% of patients and underpinnings of resistance remain undefined. METHODS: Starting with an anti-PD1 sensitive murine HNSCC cell line, we generated an isogenic anti-PD1 resistant model. Mass cytometry was used to delineate tumor microenvironments of both sensitive parental...

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Identifiers

PMID: 35058328
DOI: 10.1136/jitc-2021-004034

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