Article

Tumor-educated VEGFR-3 lymphatics augment PD-1 resistance in HPV-negative HNSCC

2026-01-28

Abstract excerpt

<title>Abstract</title> <p>The human papillomavirus (HPV) status is closely related to the response to immune checkpoint inhibitors (ICIs) in head and neck squamous cell carcinoma (HNSCC), yet the mechanisms of immunotherapy resistance in HPV-negative disease remain unclear. We integrated single-cell transcriptomics datasets to investigate the underlying driving factors of ICI resistance in HPV-negative HNSCC. Th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 40f31f05-359b-5492-a12f-7070f46bb4c7
DOI: 10.21203/rs.3.rs-8611043/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tumor-educated VEGFR-3 lymphatics augment PD-1 resistance in HPV-negative HNSCCDOI 10.21203/rs.3.rs-8611043/v1Read

The Single-Cell Landscape of Peripheral and Tumor-infiltrating Immune Cells in HPV- HNSCCSemantic proximity Read

Proliferative Exhausted CD8 T Cells Exacerbate Long-lasting Anti-tumor Effects in Human Papillomavirus Positive Head and Neck Squamous Cell CarcinomaSemantic proximity Read

Immune Heterogeneity and Intercellular Networks of HPV-Related Head and Neck Squamous Cell Carcinoma at Single Cell ResolutionSemantic proximity Read

A highly resolved integrated single-cell atlas of HPV-negative head and neck cancerSemantic proximity Read

Lymphatic-Preserving Treatment Sequencing with Immune Checkpoint Inhibition Unleashes cDC1-Dependent Antitumor Immunity in HNSCCSemantic proximity Read

Immune landscape in molecular subtypes of human papillomavirus‐negative head and neck cancerSemantic proximity Read

Comprehensive Analysis of Immune Cell Enrichment In The Tumor Microenvironment of Head And Neck Squamous Cell CarcinomaSemantic proximity Read

Immune checkpoint expression on tumor-infiltrating lymphocytes (TIL) is dependent on HPV status in oropharyngeal carcinoma (OPSCC) – A single-cell RNA sequencing analysisSemantic proximity Read

Multi-omic and immune landscapes of HPV-negative versus HPV-positive cervical cancer reveal implications for immunotherapy.Semantic proximity Read

Distinct immune evasion in APOBEC-enriched, HPV-negative HNSCCSemantic proximity Read

Distinct immune evasion in APOBEC-enriched, HPV-negative HNSCC.Semantic proximity Read

Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencingSemantic proximity Read