Article

Spatial Neuroimmune Crosstalk Driving Perineural Invasion in Head and Neck Squamous Cell Carcinoma

2026-05-29

Abstract excerpt

<h4>Background</h4> Perineural invasion (PNI) is a clinically important feature of aggressive head and neck squamous cell carcinoma (HNSCC) and is associated with recurrence and poor survival. However, the spatial organization and molecular programs that characterize tumor–nerve interactions in HNSCC remain incompletely understood. <h4>Methods</h4> Single-cell-resolution Xenium spatial transcriptomic data from 1...

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Literature Corpus work: b88be5c6-e299-52de-977c-c181fa36f4fc
DOI: 10.64898/2026.05.26.727931

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