Article

Intratumoral Heterogeneity in Ngfr+ Melanoma Subpopulations Shapes Immune Evasion and Immunotherapy Resistance

2025-05-09

Abstract excerpt

<title>Abstract</title> <p>Human melanomas dedifferentiate into a neural crest-like cell state when exposed to T cell cytokines or MAPK pathway inhibitors. This transformation is associated with cellular heterogeneity and the emergence of small, therapy-resistant melanoma populations characterized by elevated nerve growth factor receptor (NGFR) expression. However, the extent of this heterogeneity and its impact...

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Literature Corpus work: 55ae0251-623f-5ee6-873a-3197ecf7d845
DOI: 10.21203/rs.3.rs-6506453/v1

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