Article
Squamous cell carcinomas escape immune surveillance via inducing chronic activation and exhaustion of CD8+ T Cells co-expressing PD-1 and LAG-3 inhibitory receptors.
Oncotarget - 6 Dec 2016
Mishra Ameet K, Kadoishi Tanya, Wang Xiaoguang, Driver Emily, Chen Zhangguo, Wang Xiao-Jing, Wang Jing H
Abstract excerpt
Squamous cell carcinoma (SCC) is the second commonest type of skin cancer. Moreover, about 90% of head and neck cancers are SCCs. SCCs develop at a significantly higher rate under chronic immunosuppressive conditions, implicating a role of immune surveillance in controlling SCCs. It remains largely unknown how SCCs evade immune recognition. Here, we established a mouse model by injecting tumor cells derived from...
Topics
- Animals
- Antigens, CD
- Antineoplastic Agents, Immunological
- CD8 Antigens
- CD8-Positive T-Lymphocytes
- Carcinoma, Squamous Cell
- Cell Line, Tumor
- Coculture Techniques
- Cytoprotection
- Gene Deletion