Article

The Ccm3-GckIII signaling axis regulates Rab11-dependent recycling to the apical compartment

2024-05-05

Abstract excerpt

<h4>Summary</h4> Kinase cascades underlie many signaling pathways and are key regulators of development and morphogenesis. We have characterized a Hippo-like kinase cascade consisting of Thousand and One kinase (Tao), Germinal Center Kinase III (GckIII/Wheezy), and Tricornered (Trc) that plays an essential role in morphogenesis of tracheal terminal cell tubes in Drosophila . In this cascade, GckIII is the centra...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2fa3cbaf-ffce-58a0-8803-6851717aeb8f
DOI: 10.1101/2024.05.03.592387

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Ccm3-GckIII signaling axis regulates Rab11-dependent recycling to the apical compartmentDOI 10.1101/2024.05.03.592387Read

Dissection of the Role of CCM Genes in Tubulogenesis Using the Drosophila Tracheal System as a Model.Semantic proximity Read

Focal defects in single-celled tubes mutant for Cerebral cavernous malformation 3, GCKIII, or NSF2.Semantic proximity Read

CCM3/PDCD10 Heterodimerizes with Germinal Center Kinase III (GCKIII) Proteins Using a Mechanism Analogous to CCM3 HomodimerizationSemantic proximity Read

A complex of distal appendage-associated kinases linked to human disease regulates ciliary trafficking and stabilitySemantic proximity Read

Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease.Semantic proximity Read

The CCM3-GCKIII partnership.Semantic proximity Read

Rap1 and its effector KRIT1/CCM1 regulate β-catenin signalingSemantic proximity Read

Interrogating the ccm-3 Gene Network.Semantic proximity Read

CYK-4 functions independently of its centralspindlin partner ZEN-4 to cellularize oocytes in germline syncytiaSemantic proximity Read

TALPID3/KIAA0586 regulates multiple aspects of neuromuscular patterning during gastrointestinal development in animal models and humanSemantic proximity Read

CEP290 myosin-tail homology domain is essential for protein confinement between inner and outer segments in photoreceptorsSemantic proximity Read

Disrupted endosomal trafficking of the Vangl-Celsr polarity complex underlies congenital anomalies in trachea-esophageal morphogenesisSemantic proximity Read