Interrogating the ccm-3 Gene Network.

doi:10.1016/j.celrep.2018.08.039

Article

Interrogating the ccm-3 Gene Network.

Cell reports - 11 Sept 2018

Lant Benjamin, Pal Swati, Chapman Eric Michael, Yu Bin, Witvliet Daniel, Choi Soo, Zhao Lisa, Albiges-Rizo Corinne, Faurobert Eva, Derry W Brent

Abstract excerpt

Cerebral cavernous malformations (CCMs) are neurovascular lesions caused by mutations in one of three genes (CCM1-3). Loss of CCM3 causes the poorest prognosis, and little is known about how it regulates vascular integrity. The C. elegans ccm-3 gene regulates the development of biological tubes t...

Topics

Animals
Apoptosis
Apoptosis Regulatory Proteins
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Carrier Proteins
Endothelial Cells
Gene Regulatory Networks
Membrane Proteins
Mutation
Signal Transduction

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