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Article

Interrogating the ccm-3 Gene Network.

Cell reports - 11 Sept 2018

Lant Benjamin, Pal Swati, Chapman Eric Michael, Yu Bin, Witvliet Daniel, Choi Soo, Zhao Lisa, Albiges-Rizo Corinne, Faurobert Eva, Derry W Brent

Abstract excerpt

Cerebral cavernous malformations (CCMs) are neurovascular lesions caused by mutations in one of three genes (CCM1-3). Loss of CCM3 causes the poorest prognosis, and little is known about how it regulates vascular integrity. The C. elegans ccm-3 gene regulates the development of biological tubes that resemble mammalian vasculature, and in a genome-wide reverse genetic screen, we identified more than 500 possible...

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PMID: 30208312
DOI: 10.1016/j.celrep.2018.08.039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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