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Article

The CCM3-GCKIII partnership.

Histology and histopathology - 1 Oct 2013

Zalvide Juan, Fidalgo Miguel, Fraile María, Guerrero Ana, Iglesias Cristina, Floridia Ebel, Pombo Celia M

Abstract excerpt

Specific mutations in the CCM3 gene predispose to the development of cerebral cavernous malformations, a special type of vascular lesions. This calls for an elucidation of the precise nature of the CCM3 protein and a deep understanding of its molecular regulation. In this review, we outline our current knowledge of the different CCM3 protein complexes. We focus on the GCKIII family of kinases as partners of CCM3...

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PMID: 23744102
DOI: 10.14670/HH-28.1265

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