Article
Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease.
Developmental biology - 15 Feb 2012
Yoruk Bilge, Gillers Benjamin S, Chi Neil C, Scott Ian C
Abstract excerpt
Cerebral cavernous malformations (CCMs) are vascular anomalies of the central nervous system that arise due to mutations in genes encoding three unrelated proteins: CCM1 (KRIT1); CCM2 (Malcavernin/OSM) and CCM3 (PDCD10). Both biochemical and mutant studies suggest that CCM1 and CCM2 act as part of a physical complex to regulate vascular morphogenesis and integrity. In contrast, mouse Ccm3 mutant and in vitro cell...
Topics
- Animals
- Apoptosis Regulatory Proteins
- Central Nervous System Vascular Malformations
- Gene Knockdown Techniques
- Germinal Center Kinases
- Heart Defects, Congenital
- In Situ Hybridization
- Membrane Proteins
- Microtubule-Associated Proteins
- Models, Biological