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Cell type-specific <i>cis</i> -regulatory divergence in gene expression and chromatin accessibility revealed by human-chimpanzee hybrid cells

2023-05-23

Abstract excerpt

Although gene expression divergence has long been postulated to be the primary driver of human evolution, identifying the genes and genetic variants underlying uniquely human traits has proven to be quite challenging. Theory suggests that cell type-specific cis -regulatory variants may fuel evolutionary adaptation due to the specificity of their effects. These variants can precisely tune the expression of a singl...

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Literature Corpus work
2f9d4b12-09fc-559e-ada5-28f3d3a8814e
DOI
10.1101/2023.05.22.541747
Open publication

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Cell type-specific <i>cis</i> -regulatory divergence in gene expression and chromatin accessibility revealed by human-chimpanzee hybrid cellsDOI 10.1101/2023.05.22.541747
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