Article

PTPN22 R620W Gene Editing in T Cells Enhances Low Avidity TCR Responses

2022-07-22

Abstract excerpt

A genetic variant in the gene PTPN22 (R620W, rs2476601) is strongly associated with increased risk for multiple autoimmune diseases and has been linked to altered TCR regulation. Here, we utilize Crispr/Cas9 gene editing with donor DNA repair templates in human cord blood-derived, naive T cells to generate PTPN22 risk edited, non-risk edited (silent modification), or knock out T cells from the same donor. PTPN2...

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Literature Corpus work: 2f69aaea-ca75-56ee-990e-2aeef3b50d8f
DOI: 10.1101/2022.07.21.500924

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