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CRISPR-Cas9-Mediated Modification of the NOD Mouse Genome With Ptpn22R619W Mutation Increases Autoimmune Diabetes.

Diabetes - 1 Aug 2016

Lin Xiaotian, Pelletier Stephane, Gingras Sebastien, Rigaud Stephanie, Maine Christian J, Marquardt Kristi, Dai Yang D, Sauer Karsten, Rodriguez Alberto R, Martin Greg, Kupriyanov Sergey, Jiang Ling, Yu Liping, Green Douglas R, Sherman Linda A

Abstract excerpt

An allelic variant of protein tyrosine phosphatase nonreceptor type 22 (PTPN22), PTPN22(R620W), is strongly associated with type 1 diabetes (T1D) in humans and increases the risk of T1D by two- to fourfold. The NOD mouse is a spontaneous T1D model that shares with humans many genetic pathways contributing to T1D. We hypothesized that the introduction of the murine orthologous Ptpn22(R619W) mutation to the NOD...

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Source

Open in PubMed Open full text

Identifiers

PMID: 27207523
DOI: 10.2337/db16-0061
PMCID: PMC4955979

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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