Article
The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans.
The Journal of clinical investigation - 1 Sept 2011
Menard Laurence, Saadoun David, Isnardi Isabelle, Ng Yen-Shing, Meyers Greta, Massad Christopher, Price Christina, Abraham Clara, Motaghedi Roja, Buckner Jane H, Gregersen Peter K, Meffre Eric
Abstract excerpt
Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene polymorphisms are associated with many autoimmune diseases. The major risk allele encodes an R620W amino acid change that alters B cell receptor (BCR) signaling involved in the regulation of central B cell tolerance. To assess whether this PTPN22 risk allele affects the removal of developing autoreactive B cells, we tested by ELISA the reactivity of...
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