Article
The Autoimmune Risk Variant PTPN22 C1858T Alters B Cell Tolerance at Discrete Checkpoints and Differentially Shapes the Naive Repertoire.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2017
Metzler Genita, Dai Xuezhi, Thouvenel Christopher D, Khim Socheath, Habib Tania, Buckner Jane H, Rawlings David J
Abstract excerpt
A common genetic variant in the gene encoding the protein tyrosine phosphatase nonreceptor type 22 (PTPN22 C1858T) has been linked to a wide range of autoimmune disorders. Although a B cell-intrinsic role in promoting disease has been reported, the mechanism(s) through which this variant functions to alter the preimmune B cell repertoire remains unknown. Using a series of polyclonal and transgenic self-reactive...
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