Article

Perturb-seq identifies TCF7 as a central nexus linking MAPK- and Wnt-driven gene expression

2025-12-16

Abstract excerpt

<h4>ABSTRACT</h4> The MAPK pathway is a central signaling cascade whose dysregulation contributes to numerous diseases. While its upstream regulation is well studied, the mechanisms by which MAPK activation leads to diverse transcriptional outcomes remain incompletely understood. To address this shortcoming, we mapped the target gene sets controlled by 22 RAF-inducible transcription factors using targeted Perturb...

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Literature Corpus work: 298d598c-5569-5600-aa13-aa79bff4d6c9
DOI: 10.64898/2025.12.15.694273

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