Back to search

Article

TWEAK/Fn14 signalling driven super-enhancer reprogramming promotes pro-metastatic metabolic rewiring in Triple-Negative Breast Cancer

2024-05-17

Abstract excerpt

Triple Negative Breast Cancer (TNBC) is the most aggressive breast cancer subtype suffering from limited targeted treatment options. Following recent reports correlating Fn14 receptor overexpression in ER-negative breast cancers with metastatic events, we show that Fn14 is specifically overexpressed in TNBC patients and associated with poor survival. We demonstrate that constitutive Fn14 signalling rewires the tra...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b89abe3b-2ef5-5334-b622-9df1cff8ffeb
DOI
10.1101/2024.05.15.594291
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
TWEAK/Fn14 signalling driven super-enhancer reprogramming promotes pro-metastatic metabolic rewiring in Triple-Negative Breast CancerDOI 10.1101/2024.05.15.594291
TWEAK/Fn14 signalling driven super-enhancer reprogramming promotes pro-metastatic metabolic rewiring in triple-negative breast cancerSemantic proximity
Dissection of triple-negative breast cancer microenvironment and identification of potential therapeutic drugs using single-cell RNA sequencing analysisSemantic proximity
Single-cell RNA sequencing reveals route-specific remodeling of the tumor microenvironment and identifies predictive factors of breast cancer metastasisSemantic proximity
Spatial Transcriptomics of TNBC tumours and corresponding lymph node metastasis reveals immune hubs driven by TNF/NF-κB signalling of TMSB4X and CD74 expressing cellsSemantic proximity
Heterogeneity and transcriptional drivers of triple-negative breast cancerSemantic proximity
Migratory Tumor Cells Cooperate with Cancer Associated Fibroblasts in Hormone Receptor-Positive and HER2-Negative Breast CancerSemantic proximity
Single-cell profiling of synchronous multi-organ metastasis reveals a systemic CD74 <sup>+</sup> lipid-associated macrophage niche driving polymetastatic breast cancerSemantic proximity
Crosstalk between Immune Checkpoint Modulators, Metabolic Reprogramming and Cellular Plasticity in Triple-Negative Breast CancerSemantic proximity
Spatial Gene Expression Analysis Reveals Drivers of Extremely Early Lymph Node Metastasis in Breast CancerSemantic proximity
Combined Single‐Cell and Spatial Transcriptomics Reveal the Metabolic Evolvement of Breast Cancer during Early DisseminationSemantic proximity
MYC-Driven Pathways in Breast Cancer SubtypesSemantic proximity
Single-Cell and Single-Nuclei transcriptomics profiling reveals dynamic cellular features in tumor-related adipose microenvironment of breast cancer patients with high BMISemantic proximity
Select a neighboring publication to make it the new centre.