Article

ZFHX4 is necessary for dopaminergic neuron differentiation and controls cell cycle by regulating LIN28A

2025-07-04

Abstract excerpt

The selective degeneration of midbrain dopaminergic neurons (mDANs) is the main pathological hallmark of Parkinson’s disease (PD). Although many transcription factors (TFs) guiding mDAN development have been identified, the details of the underlying regulatory networks remain elusive. We have previously generated time-series transcriptomic and epigenomic profiles of human induced pluripotent stem cell (hiPSC)-deri...

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Literature Corpus work: 43498d2a-5973-519d-a534-14bcd779fa60
DOI: 10.1101/2025.07.03.662987

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