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Diversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy

17 Apr 2017

Abstract excerpt

Autophagy is an essential pathway by which cellular and foreign material are degraded and recycled in eukaryotic cells. Induction of autophagy is a promising approach for treating diverse human diseases, including neurodegenerative disorders and infectious diseases. Here, we report the use of a diversity-oriented stapling approach to produce autophagy-inducing peptides that are intrinsically cell-penetrant. These...

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PMID: 28414223
DOI: 10.1021/jacs.7b01698

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