Article

Engineered probiotics limit CNS autoimmunity by stabilizing HIF-1α in dendritic cells

2023-03-21

Abstract excerpt

<h4>Summary</h4> Dendritic cells (DCs) control the generation of self-reactive pathogenic T cells. Thus, DCs are considered attractive therapeutic targets for autoimmune diseases. Using single-cell and bulk transcriptional and metabolic analyses in combination with cell-specific gene perturbation studies we identified a negative feedback regulatory pathway that operates in DCs to limit immunopathology. Specifical...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2f28935a-7ac3-5602-9c66-55d83c7430ba
DOI: 10.1101/2023.03.17.532101

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Engineered probiotics limit CNS autoimmunity by stabilizing HIF-1α in dendritic cellsDOI 10.1101/2023.03.17.532101Read

Carboxylesterase 1 directs the metabolic profile of dendritic cells to a reduced inflammatory phenotype.Semantic proximity Read

A SREBF2-dependent gene program drives an immunotolerant dendritic cell population during cancer progressionSemantic proximity Read

Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylationSemantic proximity Read

Enhanced tumor response to adoptive T cell therapy with PHD2/3-deficient CD8 T cellsSemantic proximity Read

Lactate Increases Stemness of CD8 <sup>+</sup> T Cells to Augment Anti-Tumor ImmunitySemantic proximity Read

Glutathionylation of Pyruvate Dehydrogenase Complex E2 and Inflammatory Cytokine Production During Acute Inflammation Are Magnified By Mitochondrial Oxidative StressSemantic proximity Read

SOD1 at the Crossroads: Co-Overexpression of Canonical Antioxidant Response and Noncanonical Hydrogen Sulfide Generation Pathways in Down Syndrome, With Immune Cell ImplicationsSemantic proximity Read

“Lactic acid influences iron assimilation by a fungal pathogen via the iron reductive uptake pathway”Semantic proximity Read

Lactic Acid-Producing Probiotic Saccharomyces cerevisiae Attenuates Ulcerative Colitis via Suppressing Macrophage Pyroptosis and Modulating Gut Microbiota.Semantic proximity Read

Niche-selective inhibition of pathogenic Th17 cells by targeting metabolic redundancySemantic proximity Read

The oxygen sensor Prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cellsSemantic proximity Read

Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells induce Tfh differentiationSemantic proximity Read