Article

SOD1 at the Crossroads: Co-Overexpression of Canonical Antioxidant Response and Noncanonical Hydrogen Sulfide Generation Pathways in Down Syndrome, With Immune Cell Implications

2026-01-13

Abstract excerpt

<title>Abstract</title> <p> Accelerated immune cell aging is well-recognized feature of Down Syndrome (DS), a condition caused by trisomy of human chromosome 21 ( <italic>Hsa21</italic> ). DS predisposes individuals to recurrent infections, autoimmunity, low bone mass and leukemia. To investigate potential connections between immune cell dysfunction or disruption in DS, serum transcriptomic and proteomic datas...

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Literature Corpus work: f1900342-d455-510b-9ef8-3a68c0a0859d
DOI: 10.21203/rs.3.rs-8535243/v1

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