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A SREBF2-dependent gene program drives an immunotolerant dendritic cell population during cancer progression

2023-04-28

Abstract excerpt

Dendritic cells (cDCs) are essential mediators of anti-tumor immunity. Cancers have developed mechanisms to render DCs dysfunctional within the tumor microenvironment. Utilizing CD63 as a unique surface marker, we demonstrate that mature regulatory DCs (mregDCs) suppress DC antigen cross-presentation while driving T H 2 and regulatory T cell differentiation within tumor-draining lymph node tissues. Transcriptiona...

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Literature Corpus work
29cf3786-3a5d-50f9-8a37-7e5c41ab2164
DOI
10.1101/2023.04.26.538456
Open publication

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A SREBF2-dependent gene program drives an immunotolerant dendritic cell population during cancer progressionDOI 10.1101/2023.04.26.538456
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