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Lactic Acid-Producing Probiotic Saccharomyces cerevisiae Attenuates Ulcerative Colitis via Suppressing Macrophage Pyroptosis and Modulating Gut Microbiota.

Frontiers in immunology - 1 Jan 2021

Sun Siyuan, Xu Xiuxiu, Liang Ling, Wang Xiaoli, Bai Xue, Zhu Lanping, He Qijin, Liang Huixi, Xin Xin, Wang Li, Lou Chenxi, Cao Xiaocang, Chen Xin, Li Bingzhi, Wang Bangmao, Zhao Jingwen

Abstract excerpt

Lactic acid, a metabolic by-product of host and intestinal microbiota, has been recovered as an active signal molecule in the immune system. In this study, a lactic acid biosynthesis pathway that directly produces lactic acid from glucose rather than ethanol with high production was reconstructed in Saccharomyces cerevisiae. The engineered S. cerevisiae showed anti-inflammatory activity in dextran sulfate sodium...

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Identifiers

PMID: 34899735
DOI: 10.3389/fimmu.2021.777665
PMCID: PMC8652295

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