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Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylation

1 Feb 2024

Abstract excerpt

Lactic acid has emerged as an important modulator of immune cell function. It can be produced by both gut microbiota and the host metabolism at homeostasis and during disease states. The production of lactic acid in the gut microenvironment is vital for tissue homeostasis. In the present study, we examined how lactic acid integrates cellular metabolism to shape the epigenome of macrophages during pro-inflammatory...

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PMID: 38329873
DOI: 10.1016/j.celrep.2024.113746

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