Article

The oxygen sensor Prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cells

2021-04-20

Abstract excerpt

<title>Abstract</title> <p>The oxygen sensor PHD2 (prolyl hydroxylase domain 2) plays an important role in cell hypoxia adaptation by regulating the stability of HIF proteins (HIF1α and HIF2α) in numerous cell types including T lymphocytes. The role of oxygen sensor on immune cells, in particular on regulatory T cell (Treg) function, has not been fully elucidated. The purpose of our study was to evaluate the role...

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Literature Corpus work: afecfcd6-4747-56ca-8a8d-0ace136788a9
DOI: 10.21203/rs.3.rs-355767/v1

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