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Article

Deficiency in POLE Exonuclease Causes Synthetic Lethality in Highly Aneuploid Cancer Cells.

Cancer research - 2 Sept 2026

Kim Eun Jung, Jin Dexter X, Chibly Alejandro M, Dorighi Kristel, Sivakumar Smruthy, Kamm Jack, Juszkiewicz Szymon, Cabrera Kevin, Reja Rohit, Wang Yangmeng, Nakagawa Rachel, Shi Minyi, Liang Yuxin, Dey Anwesha, Sokol Ethan S, Gendreau Steven, He Meng

Abstract excerpt

Aneuploidy is a hallmark of cancer and is associated with drug resistance and poor clinical outcomes across diverse cancer types. However, no therapies have been clinically established to target highly aneuploid tumors. By analyzing nearly half a million tumor samples subjected to comprehensive genomic profiling, we identified a striking mutual exclusivity between POLE exonuclease domain mutations and high...

Read the complete abstract on PubMed

Topics

Humans
Aneuploidy
Synthetic Lethal Mutations
DNA Polymerase II
Cell Line, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Neoplasms

Poly-ADP-Ribose Binding Proteins

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 42258764
DOI: 10.1158/0008-5472.CAN-25-3977
PMCID: PMC13535316

Genes

POLE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 27 Oct 2026.

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Deficiency in POLE Exonuclease Causes Synthetic Lethality in Highly Aneuploid Cancer Cells.PMID 42258764Read ↗

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