Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer.

PLoS genetics - 1 Feb 2020

Fang Hu, Barbour Jayne A, Poulos Rebecca C, Katainen Riku, Aaltonen Lauri A, Wong Jason W H

Abstract excerpt

Cancer genomes with mutations in the exonuclease domain of Polymerase Epsilon (POLE) present with an extraordinarily high somatic mutation burden. In vitro studies have shown that distinct POLE mutants exhibit different polymerase activity. Yet, genome-wide mutation patterns and driver mutation formation arising from different POLE mutants remains unclear. Here, we curated somatic mutation calls from 7,345...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytosine

Share to Datasets as Topic

Share to DNA Polymerase II

Share to Poly-ADP-Ribose Binding Proteins

Share to Protein Domains

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 32012149
DOI: 10.1371/journal.pgen.1008572
PMCID: PMC7018097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer.PMID 32012149Read ↗

Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancerSemantic proximity Read ↗

Co-occurring mutations in the POLE exonuclease and non-exonuclease domains define a unique subset of highly mutagenic tumorsSemantic proximity Read ↗

POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status.Semantic proximity Read ↗

DNA polymerase epsilon catalytic subunit (POLE) in cancer: Implications for tumor biology and therapeutic strategies - A comprehensive review.Semantic proximity Read ↗

Exploring Co-occurring POLE Exonuclease and Non-exonuclease Domain Mutations and Their Impact on Tumor Mutagenicity.Semantic proximity Read ↗

DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors.Semantic proximity Read ↗

Comprehensive Analysis of Human Colorectal Cancers Harboring Polymerase Epsilon Mutations.Semantic proximity Read ↗

Comparative Analysis of Somatic and Germline Polymerase Proofreading Deficiencies in Cancer: Molecular and Clinical ImplicationsSemantic proximity Read ↗

Phenotypic POLE Variant Classification Identifies Patients Who May Have Favorable Prognosis and Benefit from Immunotherapy.Semantic proximity Read ↗

Characterization of POLE c.1373A > T p.(Tyr458Phe), causing high cancer risk.Semantic proximity Read ↗

Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to favorable survival of tumors with POLE mutations outside the exonuclease domainSemantic proximity Read ↗

Characterization of hotspot exonuclease domain mutations in the DNA polymerase ϵ gene in endometrial cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.