Article

Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes

2021-04-08

Abstract excerpt

De novo mutations in POGZ , which encodes the chromatin regulator Pogo Transposable Element with ZNF Domain protein, are strongly associated with autism spectrum disorder (ASD). Here we find that in the developing mouse and human brain POGZ binds predominantly euchromatic loci and these are enriched for human neurodevelopmental disorder genes and transposable elements. We profile chromatin accessibility and gene...

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Literature Corpus work: 7697e10c-755a-5f04-8826-5da538b3813b
DOI: 10.1101/2021.04.07.438852

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