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Article

CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum.

Nature communications - 29 Sept 2021

Reddy Naveen C, Majidi Shahriyar P, Kong Lingchun, Nemera Mati, Ferguson Cole J, Moore Michael, Goncalves Tassia M, Liu Hai-Kun, Fitzpatrick James A J, Zhao Guoyan, Yamada Tomoko, Bonni Azad, Gabel Harrison W

Abstract excerpt

Regulation of chromatin plays fundamental roles in the development of the brain. Haploinsufficiency of the chromatin remodeling enzyme CHD7 causes CHARGE syndrome, a genetic disorder that affects the development of the cerebellum. However, how CHD7 controls chromatin states in the cerebellum remains incompletely understood. Using conditional knockout of CHD7 in granule cell precursors in the mouse cerebellum, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34588434
DOI: 10.1038/s41467-021-25846-3
PMCID: PMC8481233

Genes

CHD7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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