Article
Radil controls neutrophil adhesion and motility through β2-integrin activation.
Molecular biology of the cell - 1 Dec 2012
Liu Lunhua, Aerbajinai Wulin, Ahmed Syed M, Rodgers Griffin P, Angers Stephane, Parent Carole A
Abstract excerpt
Integrin activation is required to facilitate multiple adhesion-dependent functions of neutrophils, such as chemotaxis, which is critical for inflammatory responses to injury and pathogens. However, little is known about the mechanisms that mediate integrin activation in neutrophils. We show that Radil, a novel Rap1 effector, regulates β1- and β2-integrin activation and controls neutrophil chemotaxis. On...
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