Article

Integrative Genomic and Functional Analyses Reveal NINL as a Modulator of Tau Aggregation

2025-12-16

Abstract excerpt

<h4>Introduction</h4> Proteostasis dysfunction is a hallmark of frontotemporal dementia (FTD) and Alzheimer’s disease (AD), yet the genetic and molecular pathways that disrupt protein homeostasis remain poorly understood. <h4>Methods</h4> We integrated human genetics, transcriptomics, and functional studies to identify proteostasis network components involved in tauopathy. <h4>Results</h4> We identified 18 prot...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 901dcfbf-6069-5cb6-8264-d110821a7326
DOI: 10.64898/2025.12.12.694063

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative Genomic and Functional Analyses Reveal NINL as a Modulator of Tau AggregationDOI 10.64898/2025.12.12.694063Read

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasisSemantic proximity Read

Proteostasis dysregulation is associated with astrocyte dysfunction and a KLF15–LRRTM4 regulatory axis in Alzheimer’s diseaseSemantic proximity Read

Tau interactome and RNA binding proteins in neurodegenerative diseasesSemantic proximity Read

Proteomic landscape of Alzheimer’s disease: emerging technologies, advances and insights (2021 – 2025)Semantic proximity Read

Identification of candidate genes associated with clinical onset of Alzheimer’s diseaseSemantic proximity Read

Unveiling the crucial neuronal role of the proteasomal ATPase subunit gene<i>PSMC5</i>in neurodevelopmental proteasomopathiesSemantic proximity Read

Dysregulated proteostasis network in neuronal diseasesSemantic proximity Read

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected BrainsSemantic proximity Read

Integrated multi-omics analysis reveals common and distinct dysregulated pathways for genetic subtypes of Frontotemporal DementiaSemantic proximity Read

Leveraging selective hippocampal vulnerability among Alzheimer’s disease subtypes reveals a novel tau binding partner SERPINA5Semantic proximity Read

Systems-Level Integration of Multi-Omics Identifies Genetic Modifiers of TANGO2 Deficiency Disorder.Semantic proximity Read

Comparative analysis of brain-derived tau oligomer interactomes in Alzheimer's disease, non-demented with Alzheimer's neuropathology, and primary age-related tauopathy: Implications for neurodegeneration and cognitive resilienceSemantic proximity Read