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Evolutionarily conserved regulators of tau identify targets for new therapies

6 Jan 2023

Abstract excerpt

Tauopathies are neurodegenerative diseases that involve the pathological accumulation of tau proteins; in this family are Alzheimer disease, corticobasal degeneration, and chronic traumatic encephalopathy, among others. Hypothesizing that reducing this accumulation could mitigate pathogenesis, we performed a cross-species genetic screen targeting 6,600 potentially druggable genes in human cells and Drosophila. We...

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PMID: 36610398
DOI: 10.1016/j.neuron.2022.12.012

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