Article

Decoding sequence determinants of gene expression in diverse cellular and disease states

2024-10-14

Abstract excerpt

Sequence-to-function models that predict gene expression from genomic DNA sequence have proven valuable for many biological tasks, including understanding cis-regulatory syntax and interpreting non-coding genetic variants. However, current state-of-the-art models have been trained largely on bulk expression profiles from healthy tissues or cell lines, and have not learned the properties of precise cell types and s...

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Literature Corpus work: c923316b-a88d-5cb9-96ac-45c85617d9a8
DOI: 10.1101/2024.10.09.617507

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