Article

XChrom: a cross-cell chromatin accessibility prediction model integrating genomic sequence and cellular context

2025-11-19

Abstract excerpt

Single-cell chromatin accessibility offers unique insights into transcriptional regulation beyond gene expression. However, paired datasets of these two modalities remain relatively scarce, and existing computational models cannot simultaneously predict chromatin accessibility for unseen genomic regions and cells. Here, we present XChrom, a deep learning framework for genome-wide cross-cell chromatin accessibility...

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Literature Corpus work: 5c4ef7bf-bf88-55e3-915a-82d9a38a723a
DOI: 10.1101/2025.11.18.689149

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