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Article

Trop-2 plasticity is controlled by epithelial-to-mesenchymal transition

14 Jul 2018

Abstract excerpt

The cell surface glycoprotein Trop-2 is commonly overexpressed in carcinomas and represents an exceptional antigen for targeted therapy. Here, we provide evidence that surface Trop-2 expression is functionally connected with an epithelial phenotype in breast and prostate cell lines and in patient tumor samples. We further show that Trop-2 expression is suppressed epigenetically or through the action of...

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PMID: 30010814
DOI: 10.1093/carcin/bgy095

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