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Article

A mouse neurodegenerative dynein heavy chain mutation alters dynein motility and localization in Neurospora crassa.

Cytoskeleton (Hoboken, N.J.) - 1 Sept 2012

Sivagurunathan Senthilkumar, Schnittker Robert R, Nandini Swaran, Plamann Michael D, King Stephen J

Abstract excerpt

Cytoplasmic dynein is responsible for the transport and delivery of cargoes in organisms ranging from humans to fungi. Dysfunction of dynein motor machinery due to mutations in dynein or its activating complex dynactin can result in one of several neurological diseases in mammals. The mouse Legs at odd angles (Loa) mutation in the tail domain of the dynein heavy chain has been shown to lead to progressive...

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Identifiers

PMID: 22991199
DOI: 10.1002/cm.21049
PMCID: PMC3763949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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