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Article

Analyses of dynein heavy chain mutations reveal complex interactions between dynein motor domains and cellular dynein functions.

Genetics - 1 Aug 2012

Sivagurunathan Senthilkumar, Schnittker Robert R, Razafsky David S, Nandini Swaran, Plamann Michael D, King Stephen J

Abstract excerpt

Cytoplasmic dynein transports cargoes for a variety of crucial cellular functions. However, since dynein is essential in most eukaryotic organisms, the in-depth study of the cellular function of dynein via genetic analysis of dynein mutations has not been practical. Here, we identify and characterize 34 different dynein heavy chain mutations using a genetic screen of the ascomycete fungus Neurospora crassa, in...

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Identifiers

PMID: 22649085
DOI: 10.1534/genetics.112.141580
PMCID: PMC3415999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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