Article

BAG2 Condensates Couple Proteostasis to CD8 <sup>+</sup> T Cell Surveillance

2026-04-27

Abstract excerpt

<h4>SUMMARY</h4> Protein aggregation, impaired degradation, and immune activation are central hallmarks of neurodegenerative diseases, yet how these processes are coordinated remains unclear. Here, we identify Immune-Protein Degradation Bodies (I-PDBs), a previously unrecognized class of BAG2-driven, phase-separated organelles that integrate protein quality control with adaptive immunity. IFNγ induce I-PDB format...

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Literature Corpus work: e58d9040-2d6b-5e14-aaec-c90c951795ce
DOI: 10.64898/2026.04.24.719751

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