Article

An Endocytic Checkpoint Controls Macrophage PD-1 Function and Immunotherapy Fate

2026-04-17

Abstract excerpt

Responses to PD1 blockade span durable tumor control to hyperprogressive disease (HPD), yet innate immune mechanisms governing these extremes remain undefined. Here we integrate a macrophage systems atlas (>12,500 transcriptomes) with single-cell profiles from >1,000 anti PD1 treated patients, to identify CCDC88A (GIV) as a macrophage-intrinsic determinant of durable response versus HPD. GIV loss increases PD1 sur...

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Literature Corpus work: 757a49f5-deed-5e2f-bbc9-5e1ce6e52dfe
DOI: 10.64898/2026.04.14.718292

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